I was reading Barry Mazur’s biography and come across this part:

Grothendieck was exceptionally patient with me, for when we first met I knew next to nothing about algebra. In one of his first conversations with me, he raised the question (asked of him by Washnitzer) of whether a smooth proper algebraic variety defined over a real quadratic field could yield topologically different differentiable manifolds realized by the two possible imbeddings of the number field into the reals. What a perfect question, at least for me! Not that I answered it. But it was surely one of the very few algebro-geometric questions that I then had the background to appreciate. … the question provided quite an incentive for a topologist to look at algebraic geometry. I began to learn the elements of algebraic geometry working with Mike Artin.Is the problem still open? I am an algebraic topology student so it feels very surprising someone will come up with a question like this. But I am at a loss how to experimentally find some toy examples one can work by hand.

**Answer**

Since this question has been hanging around for a few years, I think I should post Prof. Mazur’s official answer below:

Hello Bombyx mori,

Take a look at

J.-P. Serre, Exemples de variétés projectives conjuguées non homéomorphes, C. R. Acad. Sci. Paris 258 (1964), 4194-4196.

which actually gives two conjugate algebraic varieties with different fundamental groups, and therefore different homotopy types.

Best wishes,

Barry Mazur

I received the email about one year ago and forget to post it, as I am no longer active at the site. This is in fact the source of David Speyer’s blog post, so it is well known already. Whether the real quadratic case is closed I am still not sure (as I am not an expert on number fields), but hopefully this gives fellow mathematicans some encouragement to read Serre’s original paper. What Prof. Vasiu was refering to should be something similar to this paper.

**Attribution***Source : Link , Question Author : Bombyx mori , Answer Author : Bombyx mori*